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A meta-analysis of initial research showed that GLP-1s reduced the risk of major adverse cardiovascular events (MACE) in patients with type 2 diabetes (T2D) by 14%, all-cause mortality by 12%, hospital admissions for heart failure by 11%, and the composite kidney outcome by 21%

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Either path disrupts the steady-state concentration your body has adapted to, potentially reducing the medication's effectiveness and increasing side effect variability

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