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GLP-1 receptor agonists are generally well tolerated, but gastrointestinal side effects such as nausea, vomiting, and diarrhea remain common during early treatment

It is noteworthy that GIPR agonism can also attenuate PYY mediated nausea in preclinical models (89), suggesting optimism for either dual or triagonist analogues of PYY, GLP-1, and GIP

The peptide's primary mitogenic actions involve stimulation of the MAPK/ERK pathway, which promotes cell cycle progression, and the PI3K/Akt pathway, which enhances cell survival and prevents apoptosis

What is a Tirzepatide Injection