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Targeting ETC CI enhances 5FU response and extends survival The ultimate goal of better understanding mechanisms promoting 5FU tolerance is to allow us to design rational treatment combinations that are more effective than the current standard of care
For example, lean chow-fed Glp1r cell/ :Gcgr cell/ mice exhibit normal oral and IP glucose tolerance as compared to wild-type controls
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Rivera FB, Cruz LLA, Magalong JV et al (2024) Cardiovascular and renal outcomes of glucagon-like peptide 1 receptor agonists among patients with and without type 2 diabetes mellitus: A meta-analysis of randomized placebo-controlled trials
Obviously, the specific ROS probes, for instance, 2,7-dichlorodihydrofluorescein diacetate (H 2 DCFDA) for various ROS (Guler et al., 2021), dihydroethidium (DHE) for O 2 (Pongjit and Chanvorachote, 2011), and rhodamine nitroxide for OH detection (Cao et al., 2014) could be applied to determine the ROS generation in the PIPN study
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