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810,12,13 As SGLT2 inhibitors seem to mitigate the fluid retention associated with pioglitazone, this further increases their possible complementary actions

Rather than mimicking a satiety hormone, it works upstream in the central nervous system: it triggers the release of norepinephrine, dopamine, and serotonin , which suppresses appetite and modestly increases energy expenditure

As a supplement, or more specifically as a fat burner , it has been popular among athletes