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Tissue-specific source of GLP-1 after DPP-4 inhibition DPP-4 inhibitors are generally held to improve glucose homeostasis by extending the bioavailability of circulating GLP-1 derived from distal enteroendocrine L cells

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While the Wegovy pill showed a greater reduction in blood sugar, the Wegovy injection showed a greater reduction in weight

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When the PKA inhibitors (Rp-cAMP and H-89) were added, the phosphorylation of CREB and PDX1 expression were suppressed with partially activated caspase 3 (Fig

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