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After an 8-h fasting period, the rats were anesthetized with a 10% pentobarbital sodium solution administered with 25 mg/kg intraperitoneally

These dramatic results often bring equally dramatic improvements in overall health, mobility, and quality of life

The weekly dosing day may be changed if needed, provided at least 72 hours have elapsed since the previous dose

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Importantly, it also involves the braingutimmunepain axis , a bidirectional network through which the central nervous system, gut, immune cells, and peripheral nerves communicate