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Ferroptosis at the crossroads of cancer-acquired drug resistance and immune evasion
GLP-1 signaling may improve mitochondrial biogenesis via PGC-1a/nuclear respiratory factor-1/mitochondrial transcription factor A signaling regulated by adiponectin/ adenosine 5-monophosphate (AMP)-activated protein kinase (AMPK) 49 and elevates the expression of NAD-dependent protein deacetylase sirtuin 1 (SIRT1), which increases the expression of Parkin, leading to mitophagy activation
~ Nat Clin Pract Gastroenterol Hepatol
Since their debut, these novel agents have formed an important armamentarium in the management of T2DM
To further substantiate these results, we measured the expression of hexokinase 1 (HK1), a rate limiting enzyme of glycolysis