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A disruption in this system, either through a lack of leptin or resistance to it, is linked to several diseases, most notably obesity

Serious but uncommon side effects of semaglutide include pancreatitis, gallbladder disease (including gallstones and gallbladder inflammation), acute kidney injury, worsening diabetic retinopathy in people with existing eye disease, hypoglycemia when used with insulin or sulfonylureas, and severe allergic reactions such as anaphylaxis or angioedema

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Importantly, GLP-1RAs do not exert direct immunosuppressive effects but instead modulate inflammatory pathways indirectly through metabolic and cellular mechanisms, supporting a favourable safety profile when used alongside bDMARDs

It fights many diseases, particularly those associated with aging