People taking orlistat should follow a reduced-fat diet to minimise gastrointestinal side effects and may benefit from a daily multivitamin supplement, taken at a different time to the medicine
It works by helping the body manage blood sugar levels
Being first in line gives Apotex 180 days of US market exclusivity when that day comes
A specific weight-loss agent is generally continued when patients lose at least 5% of their initial body weight in the first three months without safety or tolerability concerns
The most common adverse effects of tirzepatide at weight management doses include gastrointestinal symptoms such as nausea (24-43% of patients), diarrhea (18-31%), vomiting (8-24%), constipation (16-24%), and abdominal pain (10-20%), according to the FDA label
The review confirmed that NNMT-mediated NAD+ depletion impairs mitochondrial function, SIRT activity (particularly SIRT1 and SIRT3), redox balance, and energy metabolism, creating conditions relevant to cardiovascular disease research models