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Intralineage directional Notch signaling regulates self-renewal and differentiation of asymmetrically dividing radial glia
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The usual mechanistic explanation is that the GHRH arm drives somatotroph cAMP signalling while the GHRP arm additionally attenuates somatostatin tone, so the two are acting on different limbs of the same axis rather than competing for one receptor
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Animal studies involving BPC-157 usually undergo review to ensure that endpoints are meaningful and that discomfort is minimized where possible
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