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These KO mice have increased trabecular bone fraction and reduced osteoclast number, as seen in the global IGF-I KO mice
(8) S Wrigley, D Arafa, and D Tropea (2017) Insulin-Like Growth Factor 1: At the Crossroads of Brain Development and Aging Frontiers in Cellular Neuroscience, 2017 Feb 1, Volume 11, Page 14