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However, the predictive diagnostics and functional validations need to be further addressed

For a new mother, those pressures might include lack of sleep, the physical demands of healing, and the metabolic energy required to produce milk

Lignans from flaxseed, converted to enterolactone (EL) and enterodiol by gut microflora within the intestines, possess weak estrogenic activity that competes with endogenous oestrogens for ER binding causing decreased mitogenic stimulation and lower circulating estrogen concentrations via upregulation of sex hormonebinding globulin (SHBG) (189, 190)

Heavy alcohol consumption can also contribute to this deficiency

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10.1038/nn.4000 119 FridovichI