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Like cisplatin, it contains two chloride ligands, which are released within the cellular environment and interact with DNA to form intra- and interstrand cross-links.3 These DNA adducts trigger multiple cellular responses, including DNA damage recognition and repair, cell cycle arrest, and activation of apoptotic signaling pathways, ultimately inhibiting cell proliferation.4 Ovarian cancer remains one of the leading causes of mortality among gynecological malignancies, with epithelial ovarian carcinoma accounting for more than 90% of all cases.5 The current standard therapy involves primary cytoreductive surgery followed by platinum-based combination chemotherapy administered as soon as possible after surgery.6 However, a major limitation of these treatments is the dose-dependent toxicity associated with platinum compounds, which can result in significant off-target tissue injury.7 It is well established that Reactive Oxygen Species (ROS) generated during the metabolism of platinum-based agents contribute to this toxicity, particularly in the reproductive system

Consequentially, it could lead you to experience more noticeable changes in your skin tone

A common dosage range is 100-200 micrograms per injection

Across the 39 companies we reviewed, 87% offered structured wrap-around support, including one or more of the following: Tracking and goal-setting tools Meal plans and recipes Nutrition counseling Behavioral health tools Virtual support groups or community chat Virtual workouts and exercise plans Lab monitoring 4

doi: 10.1016/j.yjmcc.2022.11.003 103 HausenloyDJBarrabesJABtkerHEDavidsonSMDi LisaFDowneyJet al

Franziskus-Hospital Cologne, (4)European Foundation for the Study of Chronic Liver Failure and Grifols Chair, Barcelona, Spain Background: Liver fibrosis is a hallmark of chronic liver disease