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The SURMOUNT-4 trial demonstrated that following 36 weeks of tirzepatide (producing 21.1% weight loss), continuing medication yielded an additional 5.5% reduction, while switching to placebo resulted in 14% weight regain

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Some may experience increased energy, improved cognitive function, or better sleep

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Maintenance (month 7+): Stable side-effect profile broadly similar to retatrutide alone, with cagrilintide adding amylin-pathway effects

Some supplement ingredients interact with medications or are contraindicated in specific health conditions