Tirzepatide is sold under the brand name Mounjaro, which is also approved only to treat type 2 diabetes
For 2024, tapentadol and dihydrocodeine were added to monitor patterns of use in-competition, and semaglutide (GLP-1 analog) was added to examine prevalence of use in sport
As a GLP-1 receptor agonist, semaglutide mimics the actions of endogenous GLP-1 but with one critical engineering advantage: while native GLP-1 has a biological half-life of only a few minutes before being cleaved by the enzyme DPP-4, semaglutide achieves a half-life of approximately seven days through structural modifications that include an Aib amino acid substitution at position 8 (blocking DPP-4 recognition) and a C18 fatty acid chain attached via a linker, which enables reversible binding to albumin in the bloodstream
[1] However, no new home for the program was ever announced
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