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GLP-1 receptor agonist therapy should be considered in all patients with type II diabetes and elevated ASCVD risk regardless of A1c or current hyperglycemic therapy

The most recent study from France titled GLP-1 receptor agonists and the risk of thyroid cancer (2) concluded that there was, in fact, an increased risk of all thyroid cancer and medullary thyroid cancer with the use of GLP-1 receptor agonists, in particular after 1-3 years of treatment

The analysis of different isoforms of cytochrome P450 (Cyp2E1, Cyp3A1 and Cyp4A10), involved in bioactivation of APAP into NAPQI, revealed a significant higher expression in transgenic mice challenged with APAP compared to control ones (Fig

The most effective approach is lifestyle changes, including a healthy, calorie-controlled diet and regular exercise

The authors would like to thank Ms Nakai (Nara Medical University) for assistance in collecting the clinical data