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Mechanism in research literature NNMT (nicotinamide N-methyltransferase) catalyses the methylation of nicotinamide using S-adenosylmethionine (SAM) as the methyl donor, producing 1-methylnicotinamide (1-MNA) and S-adenosylhomocysteine

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Its primary biological function is to protect cellular machinery from oxidative stress by neutralizing reactive oxygen species (ROS), such as superoxide radicals and hydrogen peroxide, which are natural but destructive byproducts of cellular energy production

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