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Membranes were probed with primary antibodies (all at 1:1,000 dilution) overnight at 4 C, and subsequently incubated with IRDye 800CW-conjugated goat anti-rabbit IgG or goat anti-mouse IgG (both at 1:10,000 dilution
282 Similarly, lactylation of malate dehydrogenase 2 (MDH2), a key enzyme of the TCA cycle, induces ferroptosis of cardiomyocytes by inhibiting the TCA cycle and impairing mitochondrial function, thereby resulting in myocardial ischemiareperfusion injury (MIRI)
discussion 2118
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Improved mitochondrial function is also vital for healthy aging and disease prevention
52 In a large meta-analysis by Chiang et al involving 106,395 participants and 55 RCTs, GLP-1 RA therapy was associated with an increased risk of gastroesophageal reflux disease (GERD) compared to placebo, with a reported relative risk of 2.19 (95% CI: 1.483.25)
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