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10.1038/s41586-024-07871-6 27 GuoY.HanZ.ZhangJ.LuY.LiC.LiuG

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GHK-Cus primary mechanisms include collagen stimulation (Type I and III synthesis increases of up to 70% in vitro), matrix metalloproteinase regulation (simultaneously activating MMPs for damaged matrix removal while upregulating TIMP-1/TIMP-2 for controlled remodeling), wound contraction promotion, and anti-inflammatory NF-B pathway modulation

How They Work Together The combination of glutathione and L-citrulline may provide a synergistic effect that enhances muscle performance and recovery

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For most people: Structured rehabilitation, strength training, and nutrition remain the gold standard for recoverybacked by decades of evidence