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Figure: Graph showing the risk of SIBO with different GLP-RA agents Figure: Table showing the risk of SIBO with different GLP-1 RA agents Disclosures: Lina AlQirem indicated no relevant financial relationships

Recently, a phase II multicentre, double-blind, randomized controlled trial including 338 adults with obesity were administered retatrutide (1, 2 mg starting dose increased to 4, 2 mg starting dose increased to 8, 2 mg starting dose increased to 12 mg) compared to placebo over 48 weeks [64]

Helps put less stress on the gut linings and promotes regularity*

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Specific compatibility considerations include confirmation of absence of reducing agents for disulphide-containing peptides, BSA carrier supplementation for recombinant proteins, and acetic acid acidification for hydrophobic peptides requiring low pH solubilisation

Do not change or discontinue any medications or prescribed treatments without your physician's guidance