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Clinical Applications of KLOW KLOW may be considered in patients dealing with: Musculoskeletal Injuries Tendonitis Ligament strains Muscle tears Post-surgical recovery Chronic Inflammatory Conditions Joint inflammation Autoimmune-associated tissue damage Overuse injuries Gastrointestinal Healing Increased intestinal permeability Inflammatory gut conditions Post-infectious gut dysfunction Skin and Soft Tissue Repair Accelerated aging Poor wound healing Post-procedure recovery Systemic Recovery Overtraining syndrome Chronic stress-related tissue breakdown Slow recovery from illness or injury KLOW in a Functional Medicine Framework From a functional and integrative perspective, KLOW aligns with key principles: Address root causes Support innate repair mechanisms Reduce inflammatory burden Optimize cellular communication Rather than forcing outcomes, KLOW restores signaling pathways that allow the body to heal itself more effectively

GLP-1 stands for glucagon-like peptide-1, a 30-amino-acid hormone secreted by L-cells in the small intestine after meals

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This work was supported by the Japan Society for the Promotion of Science (JSPS) Grant-in-Aid for Young Scientists (B) Grant Number JP15K19036 (SH), JSPS Grant-in-Aid for Young Scientists Grant Number JP19K16271 (SH), Japan Science and Technology Agency (JST) ACT-X Grant Number JPMJAX201A (SH), RIKEN FY2018 Incentive Research Projects (SH), and Naito Grant for female scientists after maternity leave (SH)