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CRS is characterized by fulminant activation of a large number of lymphocytes that release inflammatory cytokines and result in severe tissue damage with multi-organ dysfunction syndrome (MODS) 97
In a 4-year CV outcomes trial (Trial 7), 4,825 patients were randomized to semaglutide tablets for a median follow-up of 49.6 months and 4,825 patients were randomized to placebo for a median follow-up of 49.4 months [see Clinical Studies (14.4)]
while on the other hand, it favors the entry of SARS-CoV-2 into the oral cavity ( Figure 2 ) ( Overexpression of cytokines
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Nature 473 , 174180 (2011)
It upregulates the Anti-Inflammatory Gene Transcription Factor, and Growth Hormone receptors, all leading to better systemic repair response
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