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Mitochondrial stress-driven signaling engages AMPK- and TFEB-dependent lysosomal programs, shifting Tregs away from highly oxidative suppressive states and reducing effective tissue immune suppression, which can permit sustained inflammation and thereby worsen disease-associated immune dysregulation (32)
5A, MPTP-treated mice had significantly longer down-climbing time to the bottom of the pole compared to control mice, and the down-climbing time was prolonged with the duration of drug administration
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Fresta CG, Fidilio A, Lazzarino G, Musso N, Grasso M, Merlo S, et al
GSTZ1 expression and chloride concentrations modulate sensitivity of cancer cells to dichloroacetate
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