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Clinical data suggests that GIP co-activation with GLP-1 may also reduce nausea rates compared to GLP-1 stimulation alone, which could explain why Retatrutide and Tirzepatide cause less nausea than Semaglutide despite being more potent compounds

Elias et al., 2000)

A functional amino acid substitution in the glucose-dependent insulinotropic polypeptide receptor (GIPR) gene is associated with lower bone mineral density and increased fracture risk

Ametov, G

Strongest human evidence The METAOD006 (OPTIONS) Phase 2b trial randomized 502 adults with obesity (BMI 30-45 kg/m^2) to oral AOD-9604 (0.25, 0.5, or 1 mg/day) or placebo for 24 weeks alongside a supervised diet and exercise program

Lost 48lbs total, only 6lbs muscle loss everything else fat