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NICE guidelines recommend multicomponent lifestyle interventions as the foundation for weight management, with pharmacological options like semaglutide reserved for specific patient groups meeting eligibility criteria
Most men establish sustainable routines within 2 to 3 months that outlast the medication
GLP-1 primarily reduces appetite and slows gastric emptying, GIP enhances fat metabolism and insulin sensitivity, and glucagon increases energy expenditure and fat oxidation
Fasting glucose rises as the liver releases glucose inappropriately, and post-meal spikes become sustained elevations
