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The Endocrine Society's position is clear: FDA-approved bioidentical hormones (such as Estrace, Prometrium, or transdermal estradiol patches) should be preferred over custom-compounded formulations because approved products undergo standardized manufacturing and quality control [9]

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When I had the first loading dose I was very unwell, with severe nausea and dizziness and all over body pain- I felt like Id been hit by a bus then drugged with sleeping pills