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When glutathione is depleted - as seen in autoimmune thyroid disease - HO accumulates, causing oxidative damage to thyroid follicular cells
Its used to treat deficiencies in both vitamins at once
Most trials reported either no or minimal GSH adverse effects, but all had treatment durations of a few doses (IV) or 4 - 12 weeks
10.1016/j.nmd.2011.11.007 43 WhiteheadN
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