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Semaglutide interacts with receptors in the brain that control appetite and food intake, resulting in feelings of fullness with smaller portions
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Selective small molecule agonists have been developed to activate many of these receptors, notably G protein-coupled receptor 40 (GPR40 [free fatty acid receptor (FFAR) 1]), GPR119 and GPR120 (FFAR4), and several have shown efficacy in animal models
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