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The review positioned 5-Amino-1MQ and combined use with NAD+ precursors such as NMN as the primary research directions for investigating NNMT-targeted cardiovascular metabolic interventions in pre-clinical models

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But taking a B12 shot isn't necessary

Anti-inflammatories, including vitamin C can interact with B12 injections

Gastrointestinal Reactions (Reported/Theoretical) : Some reports suggest possible nausea or digestive discomfort, although consistent human data are lacking

The local effect theory suggests oral administration may actually work better than injection for these purposes