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Abstract The majority of anticancer agents have a reduced or even complete loss of a therapeutic effect within hypoxic tumors

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The combined improved/stable group (57.1%) demonstrated excellent survival with only 1.5% mortality, whereas the worsened group accounted for 92% of all deaths with a mortality rate of 23.5%

Indeed, systemically administered, fluorescently labeled liraglutide and semaglutide gain access to the AP/NTS [51, 52], and administration of exendin-4 into the NTS reduces food intake in rats [53]

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doi: 10.3390/ijms25094827 7 PereiraMJeyabalanJJrgensenCSHopkinsonMAl-JazzarARouxJPet al