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Metformin protected cartilage against oxidative stress by activating Nrf2 signaling in chondrocytes Intracellular ROS levels were measured by DCFH-DA

Hepatol Commun (2018) 2:58294

Auerbach, P

Subsequent optimization focused on improving potency by replacing the N-methyl-pyrazole with a 2-methylpyrimidine, yielding Compound 81