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The patient administers the medication as a once-weekly injection under the skin

Some individuals, including those with a history of pancreatitis, medullary thyroid cancer, or severe gastrointestinal disorders, should weigh risks and benefits with their healthcare provider

Most studies are small and include semaglutide used as monotherapy or combination therapy (with an insulin sodium-glucose cotransporter 2 inhibitor [SGLT2i])

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Crucially, no trial has pitted them head to head, so any comparison stitches together two studies with somewhat different lengths and participant groups