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For the colon, dissect a segment of about 3-6 cm, preferably a few millimeters below the cecum and a few millimeters above the rectum, to avoid introducing too many toxins and metabolic wastes that could contaminate the culture system, while also considering the high stem cell density in the proximal colon

Noureddin M, Rinella M, Taub R, et al

The reason is because it is a signaling molecule for your skin cells to do the things to get your skin back to normal or younger

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