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[1] Because intrinsic-factor-dependent uptake in the distal ileum can be absent in conditions such as autoimmune gastritis, pancreatic insufficiency, or bariatric surgery, the intramuscular or subcutaneous route bypasses gastrointestinal barriers and reliably restores serum concentrations

[14] Safety interpretation depends on species, exposure route, exposure duration, formulation, impurity profile, study design, and regulatory context

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American Journal of Clinical Dermatology , 16 (1), 2733