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doi: 10.1038/s41579-018-0019-y 9 ArerV.KarD

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Adipose deficiency of Nrf2 in Ob/Ob mice results in severe metabolic syndrome

Yes, especially if you have sensitive skin or have reacted to other topicals in the past

Blood Res 51(1):35 Warden SJ, Kiss ZS, Malara FA, Ooi AB, Cook JL, Crossley KM (2007) Comparative accuracy of magnetic resonance imaging and ultrasonography in confirming clinically diagnosed patellar tendinopathy