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The EC-SOD R213G polymorphism is associated with reduced exacerbations in chronic obstructive pulmonary disease (COPD) and lower rates of hospitalization [64]
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People who are vegetarians mainly rely on their endogenous production of carnitine.[ref] While the OCTN2 transporter is important in carnitine uptake, in some tissues, such as the lungs and intestines, carnitine can also be absorbed by passive diffusion.[ref][ref] The expression of the OCTN2 transporter is regulated by estrogen receptors and PPARs
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Furthermore, other recently implicated factorssuch as disruptions in the gut microbiome, excessive iodine intake, stress, and epigenetic changesfurther underscore the multifactorial nature of this disorder
This is often a reaction to the inhaler propellant or the medication itself irritating the airway lining
