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Funding This work was supported by the National Natural Science Foundation of China (82122053), CAMS Initiative for Innovative Medicine (2021-I2M-1067), Shenzhen Science and Technology Program (RCJC20221008092811025, ZDSYS20220606101604009), Shenzhen Clinical Research Center for Cancer (No.2021287), Shenzhen High-level Hospital Construction Fund, Sanming Project of Medicine in Shenzhen (SZSM202311002, SZSM202211011) and Cooperation Fund of CHCAMS and SZCH (CFA202201001, SZ2020ZD001)

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Research indicates that low-dose etoposide (2 M) can induce senescence in HepG2 liver cancer cells, while higher doses (100 M) lead to apoptosis [62]