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GFR=glomerular filtration rate
Some individuals carry genetic variants that reduce carnitine carrier expression, making supplementation more impactful for their metabolic rate and fat oxidation capacity
While enzymatic DPP-4 may be more closely related to obesity-associated inflammation and glucose regulation, soluble DPP-4 may have a distinct role that is not associated with inflammation
In this study, 475 patients were randomized
So far, early clinical data suggest amylin agonists offer milder side effects, and preclinical data support the hypothesis that their mechanism of action favors fat loss over lean mass loss
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