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Antibodies Specific primary antibodies: Akt (2532 S, 1:2000), pS473-Akt (9271 S, 1:1000), S6K (9202 S, 1:2000), pT389-S6K (9205 S, 1:1000), Stat5 (9420 S, 1:10000), and pY694-Stat5 (9356 S, 1:1000) were obtained from Cell Signaling

Ethics declarations Conflict of Interest FG Eliaschewitz and D R Franco reports consulting fees from Eli Lily, NovoNordisk, AstraZeneca, and Sanofi-Aventis

UK Biobank is a large, ongoing, prospective cohort study, with currently a median follow-up time of 11.1 years [29]

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In addition, since the prodrug is non-toxic before activation, there will be minimal dosing-related toxicity for the prodrug approach, in which a large dose could be used without severe safety concerns to overcome drug resistance