Clinically, this often overlaps with individualized titration , which is already a standard way to reduce side effects and improve adherence
Close Coordination with Your Team : Your surgeon and diabetes specialist will work together to adjust your diabetes medications based on your diet, activity level, and the stress your body is under from healing

What is already known: Irritable bowel syndrome (IBS) has 3 subtypes, including constipation-predominant, diarrhea-predominant and mixed, each with distinct pathophysiology Glucagon-like peptide-1 receptor agonists (GLP-1RAs) are increasingly prescribed for diabetes, obesity and cardiometabolic risk, but are often associated with gastrointestinal side-effects, influencing treatment adherence Real-world data on how patients with IBS tolerate GLP-1RAs are scarce What the new findings are: One-third of IBS patients prescribed GLP-1RAs for different indications switched from their initial agent, suggesting potential challenges in terms of tolerability or efficacy IBS-M showed the highest GLP-1RA discontinuation and switching rates in real-world practice Liraglutide was associated with better tolerance compared to semaglutide, with early discontinuations driven by coverage-related issues, while later discontinuations owing to side-effects or non-response In individualized GLP-1RA therapy, accounting for IBS subtype, patient-related factors are crucial for better adherence and outcomes We thank and appreciate the University of Missouri Kansas City IT department and the Department of Gastroenterology for providing their support that made this research possible

Always consult your doctor or pharmacist before making any changes to your medication routine, especially if you also use insulin or other diabetes medications
The weight-loss effects of Semaglutide, a long-acting GLP-1RA, are well-established, 9 and this was confirmed in our elderly cohort
However, if you prefer a medication with a slightly lower risk of gastrointestinal issues, liraglutide could be a more suitable alternative