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Retatrutide is a triple agonist (GIP/GLP-1/glucagon) currently in clinical trials that has shown weight loss exceeding 24% of body weight

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One of the first planned sub-analyses of SOUL will look at the potential additive effects of oral semaglutide alongside background SGLT2 inhibitor therapy

Statins alter neutrophil migration by modulating cellular Rho activity--a potential mechanism for statins-mediated pleotropic effects

Patients on azathioprine, 6-mercaptopurine, or TNF inhibitors require additional pharmacological interaction screening