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The state of hepatic GH resistance in anorexia nervosa is further corroborated by the lack of increase in IGF-I following administration of supraphysiological doses of exogenous GH in women with anorexia nervosa (61), and only refeeding appears to able to restore IGF-I levels (56, 59, 62)
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These gastrointestinal side effects are typically worse when starting treatment or after a dosage increase, but usually subside as the body adjusts to the medication within 4-8 weeks
A review on AIT pathogenesis, which discusses the importance of selenium
Phase 2 trials (Jastreboff et al., NEJM, 2023) have shown it to be highly effective for weight reduction in adults with obesity
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