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Obesity in IBD: epidemiology, pathogenesis, disease course and treatment outcomes
When hormones are optimized: Insulin sensitivity often improves Sleep quality increases Cortisol becomes more stable Muscle retention improves Energy feels more consistent Now GLP-1 and supportive peptides can work more efficiently within a balanced system rather than compensating for deeper imbalances
Advanced glycation and lipoxidation end products-amplifiers of inflammation: the role of food
In people with both type 2 diabetes and obesity, an indirect comparison drawing on the separate SURMOUNT-2 (NCT04657003) and STEP 2 (NCT03552757) trials, rather than a single head-to-head study, reported weight reduction of up to 15.7% with tirzepatide and 10.6% with semaglutide 2.4 mg
Combining these approaches often yields optimal results
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