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The meta-analysis reported several limitations since it included multiple studies

Emmons MF, Smalley KSM

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Pair with 15-30 mg zinc daily to balance copper

Melatonin, which upregulates the expression of ATP7B and GPX4 in cumulus cells, may be particularly beneficial individuals with genetic variants that disrupt metal ion homeostasis or lipid peroxidation defenses (Tsui et al., 2024)