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By promoting intestinal GLP-1 secretion through the lysosomal AMPK pathway, low-dose metformin lowers blood glucose via PEN2 in a AMP-independent manner
PMID: 10520003
Most people use the app to track food and macros, hydration and exercise
That dual action is the likely reason Mounjaro produced an average weight loss of 20.2%, compared with 13.7% for the standard Wegovy injection, in their head-to-head trial
This coincides well with histamine management, as histamine levels naturally rise throughout the day and peak in the evening
This was not statistically significant, but if the gain was from extra energy intake, could confound the results to some degree
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