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A p value was considered to be statistically significant as its value was less than 0.05

Lanjewar D, Katariya R, Kale V et al (2025) Interplay of neuropeptide Y and autophagy in Alzheimers disease: therapeutic perspectives and mechanistic insights

in fibroblast culture models it stimulates collagen, elastin, and glycosaminoglycan synthesis at picomolar to nanomolar concentrations (10 to 10 M), and modulates metalloproteinase (MMP-1, MMP-2, MMP-9) activity and their inhibitors (TIMP-1, TIMP-2), functioning as a general regulator of extracellular matrix remodeling ( Mechanistic research establishes that GHK activates TGF- and integrin 1 pathways during tissue repair, attracts immune and endothelial cells to wound sites, and restores gene expression patterns toward a healthier fibroblast phenotype in models of aging and radiation damage ( A 2018 review in IJMS characterizes its role in collagen production, nerve outgrowth stimulation, and dermal stem cell marker expression ( For Research Use Only

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Furthermore, when comparing the combination therapy to the standard treatment, Donepezil, the reduction in A plaque burden in both the cortex and hippocampus was similar between the groups, while the combination group showed a trend towards lower levels of soluble A

PubMed (peer-reviewed) (2024) 3