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Well known, the liver plays a vital and irreplaceable role in regulating physiological and biochemical balance
Additional renal effects of hyperuricemia include metabolic acidosis caused by defective lactic acid excretion which in turn exacerbates the hyperuricemia due to reduced urate excretion
Glutathione metabolism is governed by the glutathione cycle (Fig
doi: 10.1161/ATVBAHA.120.315267 204 NotzQ.HerrmannJ.SchlesingerT.HelmerP.SudoweS.SunQ.et al
