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Research into its effects on alcohol consumption is ongoing, but formal approval for alcohol-related indications would require extensive clinical trials and regulatory review

Known type 2 diabetes mellitus agents such as metformin, thiazolidinediones (TZDs), sulfonylureas, or basal insulin may also be considered

With its long-acting, once-weekly dosing and strong clinical backing, semaglutide is widely used for metabolic health management and is being explored for additional therapeutic applications

The LRP gene family is significantly upregulated in KEGG when further enriched for the Wnt pathway, including the LRP5 gene (Figure 4C)

In STEP 1, the phase 3 trial that led to semaglutide's approval for obesity, participants lost about 15% of their body weight over a year

So it cannot prove from this trial alone that retatrutide is better than existing treatments