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Phosphodiesterase-4 Inhibitors Phosphodiesterase-4 (PDE4) inhibitors, such as apremilast (Otezla), selectively target small molecules inside immune cells to correct the overactive immune response that causes inflammation in psoriatic arthritis
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It was rationally designed in the late 1980s by the team of Vladimir Khavinson at the St Petersburg Institute of Bioregulation and Gerontology, as a synthetic equivalent of the active fraction of epithalamin, a polypeptide extract of bovine pineal gland
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In a study of 14 obese horses with laminitis, all recovered successfully and resumed their previous level of soundness while following specific diet management and exercise programs
