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IGF-1 has plaque-stabilizing effects in atherosclerosis by altering vascular smooth muscle cell phenotype
Front Synaptic Neurosci 13:661476
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The same resources are needed to maintain muscle, but they are depleted by the detoxification process, leading to rapid muscle loss
This is the mechanistic basis for claims about mood and neurological effects, but the chain of inference from rodent dopamine modulation to human mood benefit is long and unvalidated
Z.NewtonY.VaskeC.et al (2020)
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